在结直肠癌中影响自然杀手细胞免疫力的干预因素:系统性审查
Wai Sinn Soh1,2,3, Grace L Burns1,2,3, Tharindu Senanayake2,3,4
1School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, Newcastle, NSW, Australia.
Cancer immunology, immunotherapy : CII
|February 1, 2025
概括
术后干预措施,包括常见的药物,如芬太尼和吗啡,以及输血,可以降低结直肠癌患者的自然杀手 (NK) 细胞功能. 这种NK细胞活动的减少可能会影响手术后的癌症免疫力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 麻醉学 麻醉学
背景情况:
- 大肠直肠癌 (CRC) 是全球领先的恶性瘤.
- 转移性疾病是一个持续的挑战,尽管手术的进步.
- 术后干预可以通过自然杀手 (NK) 细胞调节癌症免疫力.
研究的目的:
- 系统地审查标准外科手术期间干预措施对CRC患者NK细胞的影响.
- 为了确定影响NK细胞功能和数量的特定干预措施.
主要方法:
- 在四个主要数据库 (MEDLINE,EMBASE,Cochrane,Scopus) 进行系统的文献搜索.
- 遵守PRISMA系统审查指南.
- 使用Joanna Briggs Institute工具对相关研究设计进行批判性评估.
主要成果:
- 从10,404个最初的标题中,包括了16项研究.
- 与手术前水平相比,术后NK细胞数量和细胞毒性能力下降.
- 芬太尼,吗啡,普罗波,氧和输血与减少NK细胞活性有关.
结论:
- 手术压力显著影响NK细胞细胞毒性.
- 术后干预,包括胺和吗啡,对NK细胞细胞毒性产生负面影响.
- 需要进一步的研究来减轻这些对癌症免疫力的影响.
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