孕妇的饮食质量和在怀孕期间循环的细胞外囊泡和粒子miRNA
Meghan E Muse1, Yuting Wang2, Diane Gilbert-Diamond2
1Department of Epidemiology, Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH, USA. Meghan.Elizabeth.Muse@Dartmouth.edu.
European journal of nutrition
|February 1, 2025
概括
孕妇的饮食质量,特别是红肉消费,会影响怀孕期间循环的细胞外囊泡微RNA (EVP miRNA). 这些发现表明饮食,EVPmiRNA和怀孕结果之间存在潜在联系.
科学领域:
- 生殖生物学 生殖生物学
- 营养科学 营养科学
- 分子生物学分子生物学
背景情况:
- 在母体循环中的细胞外囊和颗粒微RNA (EVP miRNA) 对于母胎沟通至关重要.
- 改变的EVP小RNA和母亲饮食质量差都与不良的妊娠结果有关.
- 孕妇饮食对怀孕期间循环的EVP小RNA的影响在很大程度上仍未被探索.
研究的目的:
- 调查由替代健康饮食指数 (2010年) 评估的孕产妇饮食质量与怀孕期间孕产妇循环中的EVP miRNA水平之间的关联.
主要方法:
- 一项试点研究涉及53名来自新罕布什尔州出生队列研究的孕妇参与者.
- 使用AHEI-2010指数评估母亲的饮食质量.
- 血EVPmiRNA使用NanoString nCounter平台进行了分析,分析了798个miRNA转录,平均妊娠年龄为28.8周.
主要成果:
- 较高的AHEI-2010分数的坚持与可检测的独特miRNA转录的数量有关.
- 增加红色和加工肉类的消费量与7种特定miRNA的水平呈现出积极的关联.
- 值得注意的是,hsa-miR-512-5p是胎盘特异性染色体19 miRNA集群的一部分,与肉类消费有显著的关联.
结论:
- 红色和加工肉类摄入量与怀孕期间特定的循环EVPmiRNA水平之间发现了关联.
- 这些包括胎盘特异的miRNA和那些准涉及胎盘发育的途径.
- 需要进一步的研究来确定改变的母体EVPmiRNA是否会调解饮食质量对怀孕和分娩结果的影响.
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