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鼻内催产素增加母乳催产素,但对抑郁的母亲的影响较小:一项随机对照试验

Kate Lindley Baron-Cohen¹, Pasco Fearon², Ruth Feldman³

¹Research Department of Clinical, Educational and Health Psychology, University College London, United Kingdom; The Anna Freud National Centre for Children and Families, London, United Kingdom; Centre for Future Health, University of York, United Kingdom.

Psychoneuroendocrinology

|February 1, 2025

概括

产后抑郁症 (PND) 可能会破坏催产素 (OT) 途径. 外源性OT增加了母乳OT,但在PND症状的母亲中效果较差,这表明对母婴结合的潜在影响.

科学领域:

神经内分泌学神经内分泌学
孕产妇心理健康孕产妇心理健康
人类哺乳期哺乳期

背景情况:

催产素 (OT) 对于压力调节,母婴结合和母乳养至关重要.
产后抑郁症 (PND) 对这些关键的孕产妇功能产生负面影响.
了解OT在PND中的作用对于母亲和婴儿的福祉至关重要.

研究的目的:

为了研究母乳中的内源性催产素 (OT) 度.
为了比较外源性OT给药与安慰剂对母亲母乳OT水平的影响.
探索PND症状对OT水平和对外源OT的反应的影响.

主要方法:

一个双盲,随机对照试验,涉及62名母亲和他们的婴儿 (3-9个月).
母亲使用爱丁堡产后抑郁症量表 (EPDS) 选PND症状.
在母乳养期间采集母乳样本,并在鼻喷雾剂 (外源性OT或安慰剂) 施用前后对OT含量进行分析.

主要成果:

基线母乳OT度与母亲的低情绪没有相关性.
外源性OT鼻喷雾显著增加了母乳OT水平.
与对照人群相比,在异源剂后母乳OT的增加在患有PND症状的母亲中减少.

结论:

在母乳养期间,孕产妇的PND可能会破坏中枢和外围催产素通路之间的相互作用.
母乳OT对PND相关的发育缺陷的潜在保护作用需要进一步研究.
这些发现提供了对孕产妇心理健康脆弱性向婴儿传播的生物学机制的见解.

关键词:

母乳是母乳中的一种.情绪情绪情绪氧化素是一种氧化素.产后抑郁症产后抑郁症

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