肠道的脊柱感官内置
1Department of Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA; Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Current opinion in neurobiology
|February 1, 2025
概括
背部根 (DRG) 中的脊柱感觉神经元在胃肠道 (GI) 整体感知中发挥着至关重要的作用. 最近的研究揭示了它们在肠道传感中的多样性功能,以前被道所掩盖.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 感官生物学 感官生物学
背景情况:
- 内感觉,感知身体内部的环境,对于生理功能至关重要,如食欲控制和病理状况,如腹痛.
- 胃肠道 (GI) 路的感觉内化涉及脊柱感觉神经元 (背部根中的细胞体,DRG) 和阴道感觉神经元 (结节中的细胞体).
- 虽然阴道通路得到了充分的研究,但DRG感觉神经元对肠道内接收的贡献仍然不太了解.
研究的目的:
- 审查了解肠道阻断DRG感觉神经元的特性和功能的最新进展.
- 突出目前关于DRG感官神经元在肠道内感受中的作用的知识差距.
- 为了强调这种未被充分研究的神经元群体在内肠传感中的重要性.
主要方法:
- 关于DRG和静脉感官神经元激活肠道的最近研究的文献综述.
- 综合了关于肠内激活DRG神经元的多样性和功能的当前发现.
- 确定需要在GI互感受领域进行进一步调查的领域.
主要成果:
- DRG 感觉神经元具有多种特性,在胃肠道感知中起着重要作用.
- 最近的研究开始阐明这些神经元在整体感受中的特定功能.
- 关于DRG神经元对肠道感应的全部贡献,仍然存在重大知识差距.
结论:
- 肠道内置的DRG感觉神经元是关键的,但尚未研究的,肠道内感受的组成部分.
- 对DRG神经元功能的进一步研究对于全面了解内体感应至关重要.
- 了解DRG的作用可能为GI病理生理学和治疗点提供新的见解.
相关概念视频
Nerve Supply of the GI Tract
968
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
968
Spinal Nerves: Anatomy
2.0K
Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
2.0K
Spinal Nerves: Plexus II
473
The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
473
Spinal Cord
397
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
397
Spinal Cord: Information Processing
1.1K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
1.1K
Spinal Nerves: Plexus I
716
Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
716


