野生蝙蝠抗生素耐药基因的饮食驱动多样性:对公共卫生的影响
Long Huang1, Wentao Dai1, Xiaoyu Sun1
1Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization, Northeast Normal University, Changchun, China.
Microbiological research
|February 1, 2025
概括
野生蝙蝠拥有众多抗生素耐药性基因 (ARG),构成公共卫生风险. 饮食显著影响肠道抵抗性,蝙蝠作为抗生素耐药性基因传播的潜在载体.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 环境科学 环境科学
背景情况:
- 野生蝙蝠可以作为抗生素耐药基因 (ARG) 和抗生素耐药细菌的储存库.
- 现有的关于蝙蝠抗生素耐药性的研究仅限于依赖培养的方法,提供不完整的见解.
研究的目的:
- 使用元基因组学研究蝙蝠饮食,肠道微生物群和抵抗体之间的关联.
- 在具有多样化的饮食习惯的蝙蝠中描述ARG和移动遗传元素 (MGE).
- 评估野生蝙蝠中发现的ARG对公共卫生的影响.
主要方法:
- 来自五种不同的饮食 (果食,昆虫食,鱼食,肉食,血食) 的蝙蝠肠内容的元基因组测序.
- 对肠道微生物群组成,ARG概况和移动遗传元素 (MGE) 的分析.
- 识别和量化ARG及其水平基因转移潜力.
主要成果:
- 在蝙蝠肠中发现了大量的ARG (1106种) 产生对26种抗生素的耐药性.
- 特别普遍的是多药耐药性和多素耐药性基因.
- 在不同饮食群体中观察到ARG和MGE丰度/多样性的显著变化,与微生物组成有关.
- 在动物性传染病原体中发现了高风险ARG和MGEs之间的遗传联系,这表明了潜在的人类健康风险.
结论:
- 蝙蝠是ARG传播的重要载体,饮食在塑造肠道抗体中起着至关重要的作用.
- 蝙蝠中动物传染病原体上ARG的存在凸显了对人类健康的潜在威胁.
- 甲基因组分析提供了对野生动物相关的抗菌素耐药性的全面了解.
更多相关视频
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
6.3K
06:54Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
Published on: July 19, 2024
943
相关概念视频
Antibiotic Selection
52.2K
Overview
52.2K
Genomic DNA in Prokaryotes
43.3K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.3K
Bacterial Transformation
55.1K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
55.1K
Mutation, Gene Flow, and Genetic Drift
57.9K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
57.9K
Convergent Evolution
27.4K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.4K
Viral Mutations
32.1K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.1K
