系统审查和个人参与者数据的元分析:减少青少年的自我伤害:聚合治疗效果,研究,治疗和参与者主持人
Alex Wright-Hughes1, Amanda J Farrin1, Peter Fonagy2
1University of Leeds, Leeds, United Kingdom.
Journal of the American Academy of Child and Adolescent Psychiatry
|February 1, 2025
概括
这次元分析没有发现任何证据表明,治疗干预措施可以防止青少年重复自我伤害. 然而,干预措施对有多次先前自我伤害事件的青少年来说是有希望的.
科学领域:
- 青少年心理健康 青少年心理健康
- 公共卫生干预措施 公共卫生干预
- 临床试验方法论 临床试验方法论
背景情况:
- 自伤是青少年中一个重要的公共卫生问题.
- 缺乏有效的干预措施来防止自我伤害的重复.
- 这项研究解决了对治疗效果的强有力的证据的需求.
研究的目的:
- 评估治疗干预措施在减少青少年反复自我伤害方面的有效性.
- 确定哪些干预措施最适合特定的青少年子组.
- 通过对随机对照试验的个人参与者数据元分析提供强有力的证据.
主要方法:
- 系统地搜索数据库和试验登记册,直到2022年1月.
- 包括随机对照试验 (RCT),将治疗干预措施与对照组进行比较.
- 进行了双阶段随机效应的个人参与者数据 (IPD) 分析.
主要成果:
- 没有显著的证据表明,干预措施可以防止在12个月后重复自我伤害 (IPD 或1.06;组合数据或1.02).
- 没有证据表明在研究或治疗因素之间治疗效果的异质性.
- 之前有多次自我伤害事件的参与者表现出治疗效果的改善 (OR 0.33).
结论:
- 目前的治疗干预措施在减少青少年反复自我伤害方面没有整体有效性.
- 有证据表明,在有两次或多次自伤事件的青少年中,干预措施可能是有效的.
- 建议在未来的研究中采用标准化的结果措施.
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