低工作记忆支持了疼痛调节电路的异常功能性质和慢性背痛严重程度之间的关联
Jennika Veinot1, Douglas Cane2, Javeria Ali Hashmi1
1Department of Anesthesia, Pain Management & Perioperative Medicine, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada; Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
The journal of pain
|February 1, 2025
概括
慢性腰痛患者的工作记忆缺陷与疼痛严重程度有关. 工作记忆受损会通过背侧前额叶皮层-外水管道灰色通路影响疼痛调节.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 认知科学 认知科学
背景情况:
- 工作记忆障碍在慢性腰痛 (CLBP) 中很普遍,与疼痛严重程度的增加相关.
- 工作记忆的减少可能会通过阻碍威胁的上下文化和疼痛调节来加剧慢性疼痛.
- 背侧前额皮层 (dlPFC) 和周水管灰层 (PAG) 对这些认知疼痛过程至关重要.
研究的目的:
- 为了研究工作记忆的变化如何影响dlPFC-PAG通路激活和连接在疼痛调节任务期间的CLBP患者.
- 确定工作记忆,威胁偏差和CLBP疼痛严重程度之间的关系.
- 探索dlPFC-PAG功能连接在预测工作记忆变化和疼痛中的作用.
主要方法:
- 在患有CLBP的个体中使用疼痛调制 (方案) 任务评估工作记忆的变化和威胁偏差.
- 在低和高威胁条件下测量dlPFC和PAG激活.
- 检查了dlPFC和PAG之间的基线功能连接.
主要成果:
- 在低威胁条件下,工作记忆精度降低与dlPFC和PAG激活率增加相关.
- 在高危条件下,减少dlPFC-PAG激活与更大的慢性疼痛和较差的工作记忆有关.
- 基线dlPFC-PAG功能连接性预测了工作记忆的变化和CLBP严重程度.
结论:
- 工作记忆和疼痛调制在dlPFC-PAG路径中融合.
- 这个通路的激活和连接的异常有助于慢性疼痛.
- 这些发现突出了认知和疼痛相互作用,并建议针对工作记忆和dlPFC-PAG途径进行治疗干预.
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