FGF1通过抑制脂质的作用减轻聚乙烯纳米塑料诱导的神经炎症
Bo Qian1, Chen-Qiang Wang1, Zou Su2
1Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, School of Public Health, Guilin Medical University, Guilin, China.
International journal of biological macromolecules
|February 1, 2025
概括
聚乙烯纳米塑料 (PS-NPs) 通过激活脂质会触发神经炎症. 纤维细胞生长因子 (FGF1) 通过抑制脂质和改善认知功能,对PS-NP产生神经保护作用.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
背景情况:
- 全球纳米塑料 (NP) 污染引发了健康问题.
- 对NP神经毒性的理解有限.
- 聚乙烯纳米塑料 (PS-NP) 是普遍存在的环境污染物.
研究的目的:
- 研究PS-NPs的神经毒性作用和机制.
- 探索脂质在PS-NP诱导的神经炎症中的作用.
- 评估纤维细胞生长因子 (FGF1) 的潜在神经保护作用.
主要方法:
- 采用PS-NP的体外和体内暴露模型.
- 分析脂,脂溶和炎症媒介产生的情况.
- RNA测序以识别分子途径.
- 在暴露于PS-NP模型中的外源性FGF1处理.
- 评估小鼠的认知功能和神经病理损伤.
主要成果:
- 暴露于PS-NPs激活了与脂质相关的脂解,促进了脂质炎症介质 (2-阿拉基多尼尔甘油和前列腺素E2) 和神经炎症.
- 纤维细胞生长因子 (FGF1) 与脂质细胞活化有负相关性.
- 外源性FGF1通过抑制脂质抑制了PS-NP诱导的神经炎症和脂质积累.
- 在小鼠中,FGF1治疗缓解了PS-NP诱导的学习和记忆缺陷以及神经病理损伤.
结论:
- 通过脂质细胞活化和改变脂质代谢,PS-NPs诱导神经毒性和神经炎症.
- FGF1充当神经保护因子,防止PS-NP引起的神经损伤.
- FGF1通过重塑中枢神经系统中的脂质代谢来发挥其保护作用.
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