在慢性无能症患者的速度适应性节奏的有效性:随机对照试验的系统综述和元分析
Shunsuke Kuroda1, Iwanari Kawamura2, Yuki Sahashi3
1Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
International journal of cardiology
|February 1, 2025
概括
速度适应节奏 (RAP) 改善了慢性无能症患者的运动能力和心率. 然而,心力衰竭患者的益处较小,因此需要对先进疗法进行仔细评估.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 运动生理学 运动生理学
背景情况:
- 速度适应性节奏 (RAP) 旨在优化心率 (HR) 响应在患有节律器和慢性无能症的患者.
- 之前的研究表明,RAP对运动能力有多种改善,需要进一步评估.
研究的目的:
- 系统地评估RAP模式在不同临床环境中的有效性.
- 分析RAP对运动能力和患者报告结果的影响.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 包括12项随机对照试验 (1199名患者),比较RAP启动模式与RAP关闭模式.
- 分析氧气吸收峰值 (VO2),运动持续时间和患者报告的结果 (PRO).
主要成果:
- RAP-on显著改善了峰值VO2 (1.35毫升/千克/分钟) 和运动持续时间 (0.74分钟),并增加了峰值HR (19bpm).
- 与没有心力衰竭 (HF) 的患者相比,RAP的有效性在心力衰竭 (HF) 的患者中减弱.
- 随着RAP-on的使用,没有观察到PRO的显著改善,除了一个非HF研究外.
结论:
- 在慢性无能症患者中,RAP-on增强了运动能力,但在患有HF的患者中,其益处减少了.
- 对于RAP-on的HF患者来说,仔细评估至关重要,以确定是否需要先进的治疗策略.
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