在2型糖尿病中改变了基于个体的形态脑网络
Wang Yan1, Ge Limin1, Sun Zhizhong1
1Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou, China.
Brain research bulletin
|February 1, 2025
概括
2型糖尿病 (T2DM) 改变大脑网络连接,影响认知功能. 这些大脑网络变化,特别是特定区域和子网络的变化,与T2DM患者的认知表现有关.
科学领域:
- 神经成像是一种神经成像.
- 医学神经科学 医学神经科学
- 系统神经科学 系统神经科学
背景情况:
- 2型糖尿病 (T2DM) 是一种已知的认知能力下降的风险因素.
- 破坏大脑网络连接是将T2DM与认知障碍联系起来的潜在机制.
- 有限的研究存在于T2DM中的基于个体的形态脑网络及其临床相关性.
研究的目的:
- 在T2DM患者中研究基于个体的形态大脑网络 (MBNs) 的拓性质.
- 探索MBN变化,临床特征 (HbA1c) 和T2DM认知表现之间的关联.
- 确定受T2DM影响的特定脑子网络及其对认知功能的预测价值.
主要方法:
- 利用图形理论分析了123名T2DM患者和91名健康对照者的形态大脑网络 (MBNs).
- 使用对称的Kullback-Leibler (KL) 基于分歧的相似性 (KLS) 构建网络.
- 计算全球和节点网络指标以评估拓性质并识别改变的连接模式.
主要成果:
- T2DM患者在特定的大脑区域的结节程度增加,包括左侧准海马体,左侧杏仁体,左侧前体,双侧体和右侧下圈.
- 糖化血红蛋白 (HbA1c) 度与左前结节点程度正相关.
- 在T2DM中确定了与认知表现相关的低连接子网络 (奖励电路) 和超连接子网络 (注意网络).
结论:
- 这项研究提供了神经成像证据,证明T2DM中变化的形态大脑网络拓.
- 特定的大脑区域和子网络与T2DM相关的认知变化有关.
- 形态大脑网络特性可以作为T2DM认知表现的潜在生物标志物.
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