皮克林乳液的局部传递性能通过不同电荷的螺旋蛋白分离物/Chitosan复合颗粒稳定
Xiaoyuan Qiu1, Danni Yan1, Linghui Xu1
1Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122 China.
International journal of pharmaceutics
|February 1, 2025
概括
含有螺旋ulina 蛋白质隔离物 - 基托颗粒的正电荷皮克林乳液有效地局部输送α-Bisabolol (ABS). 这些稳定的乳液增强了皮肤的保留力,特别是在角层中,优化了局部药物输送.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 合体和表面化学
背景情况:
- 皮克林乳液由颗粒物稳定,提供先进的局部输送解决方案.
- 螺旋蛋白分离物 (SPI) 和奇托 (CS) 复合颗粒为稳定这些乳液提供了一种新的方法.
研究的目的:
- 通过使用由不同电荷的SPI-CS复合颗粒稳定的皮克林乳液来研究α-Bisabolol (ABS) 的局部递送疗效.
- 探索粒子电荷对ABS皮肤透和保留的影响.
主要方法:
- 通过静电组件合成SPI-CS复合颗粒.
- 使用泽塔电位测量的粒子电荷的表征.
- 皮克林乳液的制备和稳定性评估.
- 在体外皮肤透研究和光谱分析 (ATR-FTIR).
主要成果:
- 所有SC稳定皮克林乳液都在30天内表现出稳定性,具有高的ABS封装效率.
- 带正电荷的乳液显著增强了角层中ABS的保留.
- 颗粒度和油相体积分被优化为局部输送.
结论:
- SPI-CS复合物颗粒的电荷在调节ABS的局部输送和皮肤保留方面发挥着至关重要的作用.
- 优化的皮克林乳液显示出有效的局部输送系统的潜力.
相关概念视频
Colloidal precipitates
494
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
494
Colloids
17.3K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
17.3K


