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两个月后的认知变化提高了临床高风险个体非缓解的预测
TianHong Zhang1, YanYan Wei1, XiaoChen Tang1
1Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
Biological psychiatry
|February 1, 2025
概括
患有精神病临床高风险 (CHR) 个体的短期认知变化显著预测非缓解. 然而,认知变化并没有改善超出基线评估的转化为精神病的预测.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 纵向认知变化对于预测临床高风险 (CHR) 个体的结果至关重要.
- 对CHR个体来说,评估基线认知障碍和短期变化至关重要.
- 与健康对照组 (HCs) 的比较为认知功能提供了一个基准.
研究的目的:
- 研究基线认知功能和短期认知变化的预测价值.
- 确定认知变化预测非缓解和转化为精神病在CHR个人的能力.
- 为了比较CHR个体和HC之间的预测值.
主要方法:
- 进行了一项前性研究,并进行了3年的随访.
- 在基线和2个月后的随访中评估了CHR个体和HC.
- 使用了中国版本的测量和治疗研究以改善精神分裂症认知 (MATRICS) 共识认知电池.
主要成果:
- 短期的认知变化显著改善了CHR个体非缓解的预测 (AUC从0.690增加到0.819).
- 非缓解的关键预测因素包括口头学习和空间/视觉空间记忆.
- 2个月的认知变化并没有显著改善转化为精神病的预测 (基线AUC:0.667;变化的AUC:0.666).
结论:
- 动态认知监测对于CHR个体很重要.
- 短期的认知变化增强了非缓解的预测,但不能转化为精神病.
- 语言学习和工作记忆是预测CHR个体临床结果的关键认知领域.
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