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相关概念视频

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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重新定义维生素D的状态:通过大数据分析建立基于人口的间接参考间隔.

Aleix B Fabregat-Bolufer1, Alba Escolà-Rodríguez2, José Luís Bedini-Chesa1

  • 1Biochemistry and Molecular Genetics Department, CDB, Hospital Clínic of Barcelona, Barcelona, Spain.

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概括

准确的维生素D (25-基维生素D) 参考间隔是使用现实数据建立的,根据性别,季节和检测方法显示出显著的差异. 调整这些间隔可以优化查和补充,减少与维生素D评估相关的风险.

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科学领域:

  • 临床化学 临床化学
  • 内分泌学 在内分泌学.
  • 公共卫生 公共卫生

背景情况:

  • 精确的血清25-氧维生素D [25(OH) D]参考间隔对于诊断维生素D缺乏和指导补充至关重要.
  • 现有的RI可能无法充分反映多样化的人口或考虑到不同测量方法,人口统计和季节性因素带来的变化.
  • 该refineR算法提供了一种方法,可以使用现实世界数据 (RWD) 来建立间接的RI.

研究的目的:

  • 在巴塞罗那使用refineR间接方法和RWD建立精确的,基于人群的血清25(OH) D的RI,使用refineR间接方法和RWD.
  • 调查人口 (性别,年龄),方法 (测试) 和季节性因素对血清25...OH) D水平的影响.
  • 评估研究人口中维生素D缺乏和严重缺乏的流行情况.

主要方法:

  • 在2018年至2022年期间采集的130,030个血清25(OH) D样本的回顾性分析.
  • 样品使用VDSP认证的Liaison和Atellica免疫测试进行测量.
  • 使用带有Box-Cox转换的refineR算法来建立RI,分析人口,试验,部门和季节变化.

主要成果:

  • 血清中位数25(OH) D为25 ng/mL;34.2%的样本显示缺乏 (≤20 ng/mL) 和12.6%的严重缺乏 (≤12 ng/mL).
  • 修改后的Box-Cox转换产生了14.2-65.9 ng/mL的RI,在性别,测试 (Liaison: 10.2-58.6 ng/mL,Atellica: 9.9-59.3 ng/mL) 和患者组之间观察到差异.
  • 发现了显著的季节性变化,夏季25OH) D水平较高;门诊患者和内分泌学患者的RI最低.

结论:

  • 该refineR算法成功地确定了血清25(OH) D的特定人群RI,突出显著的人口和季节性影响.
  • 根据特定人群的数据重新定义25...OH) D值可能会减少不必要的查和补充,从而最大限度地降低相关风险.
  • 这项研究强调了实施人口,季节和方法特定的RI的必要性,以改善维生素D评估和临床管理.