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Updated: May 29, 2025

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

Published on: September 1, 2018

引发了自发流产,因为它破坏了子宫内膜 stromal 细胞的决定性

Xue-Ke Zhang¹, Xuan Li¹, Xing-Xing Han¹

¹Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei, Anhui 230032, China.

|February 1, 2025

概括

决定中的积与自发性流产 (SA) 有关. 这种有毒金属通过降低关键基因的调节,增加SA风险并提供新的预防策略,从而损害了分离.

科学领域:

生殖生物学生殖生物学
环境毒理学环境毒理学
产科和妇科产科和妇科

背景情况:

(Cd) 是一种有毒的重金属,在器官中积累.
对于Cd积累在受损决定和自发流产 (SA) 中的作用尚不清楚.

研究的目的:

为了研究度Cd和SA之间的关联.
确定Cd积累是否影响决定化,并阐明底层机制.

主要方法:

在SA患者中分析了decidual Cd水平和decidualisation标记物 (prolactin,IGFBP1).
建立了一个子宫特定的Cd积累小鼠模型,以评估胎儿的结果和决定性化.
用于体外培养的人体子宫内膜层细胞 (hEnSCs) 来检查Cd对决定和基因表达的影响.

主要成果:

果断的Cd度升高,与SA发生有正相关.
抗胰岛素患者表现出降低了决定性标记物,益乳素 (PRL) 和胰岛素样生长因子结合蛋白1 (IGFBP1) 的水平.
积累了Cd的小鼠显示胎儿吸收增加和缺陷的决定性;在体外,Cd抑制了hEnSCs的决定性,并降低了关键调节基因 (PGR,ESR1,ESR2,FOXO1).

结论:

通过对PRL和IGFBP1.1的上游监管机构进行下调调节,Cd的积累会损害分体化.
这种机制增加了自发流产的风险.
研究结果表明,通过管理Cd暴露来预防和治疗SA的新途径.

关键词:

是的组成部分.决心实现二元化胚胎内膜层细胞胚胎内膜层细胞自发流产是一种自发的流产.子宫特定积累的子宫特定积累.

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