孕期克洛桑暴露及其对儿童神经发育的影响 - - 系统性审查
Aleksander Brandão Santana1, Lídia EmmanuelaWiazowski Spelta2, Joselin Valeska Martinez-Sobalvarro3
1Department of Food and Drugs, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, Brazil.
Reproductive toxicology (Elmsford, N.Y.)
|February 1, 2025
概括
产前暴露于 triclosan (TCS) 显示有限的证据导致儿童的神经行为问题. 虽然一些研究表明存在潜在的缺陷,但大多数研究没有发现显著的影响,这表明需要对这种常见的抗菌剂进行进一步研究.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 特里克洛桑 (TCS) 是一种广泛使用的抗菌剂.
- 暴露于TCS与内分泌干扰和潜在的健康风险有关.
- 关于产前TCS暴露和神经行为结果的数据有限.
研究的目的:
- 系统地审查有关产前暴露于triclosan和神经行为障碍的观察性研究.
- 综合有关母亲TCS暴露与儿童神经发育之间的关联的证据.
主要方法:
- 在多个数据库中进行系统的文献搜索,截至2024年2月.
- 纳入了14项考察孕妇接触TCS的队列研究.
- 数据提取,质量评估 (Downs and Black) 和证据评估的 GRADE 确定性.
主要成果:
- 四项研究表明,产前TCS暴露与神经发育缺陷 (如注意力,多动性) 之间存在潜在关联.
- 八项研究发现,产前TCS暴露与不良神经行为结果之间没有显著的关联.
- 由于研究异质性和混因素,证据的整体确定性被评估为低.
结论:
- 目前关于产前暴露于triclosan和神经行为障碍的证据是不确定的.
- 需要进一步进行高质量的研究来证实或反驳潜在的联系.
- 由于TCS的广泛使用,需要继续调查其对发育的毒性.
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