精神疾病和腹腔大动脉动脉瘤之间的因果关系:从遗传角度的见解
Ming-Gang Deng1, Chen Chai2, Kai Wang3
1Department of Psychiatry, Wuhan Mental Health Center, Wuhan 430012, Hubei, China; Department of Psychiatry, Wuhan Hospital for Psychotherapy, Wuhan 430012, Hubei, China.
Progress in neuro-psychopharmacology & biological psychiatry
|February 1, 2025
概括
基因预测的抑郁症和精神分裂症增加了腹腔大动脉瘤 (AAA) 的风险. 传统的AAA风险因素,如吸烟和高血压,调解了这些联系,突出了共同的途径.
科学领域:
- 遗传学 是一个遗传学.
- 心血管疾病 心血管疾病
- 精神病学是一个精神病学.
背景情况:
- 研究精神健康状况和腹腔大动脉动脉瘤 (AAA) 之间的遗传重叠对于了解疾病病因至关重要.
- 抑郁症,精神分裂症 (SCZ) 和双相情感障碍 (BIP) 是常见的精神障碍,具有复杂的遗传基础.
- 腹腔大动脉瘤 (AAA) 是一种危及生命的血管疾病,具有显著的遗传成分.
研究的目的:
- 探索主要精神障碍和腹腔大动脉瘤 (AAA) 之间的遗传关联和因果关系.
- 确定共享的遗传位置,并评估传统风险因素在精神疾病和AAA之间的联系中扮演的调解角色.
主要方法:
- 使用链接不平衡得分回归 (LDSC) 和GNOVA进行全球遗传相关性分析.
- 使用SUPERGNOVA进行局部遗传相关性,并使用pleioFDR识别共享的遗传位置.
- 应用单变量和多变量门德尔随机化 (MR) 来评估因果关系,随后进行中介分析.
主要成果:
- 在抑郁症,精神分裂症 (SCZ) 和AAA之间发现了显著的积极遗传相关性,但不是双相情感障碍 (BIP).
- 确定了许多AAA与抑郁症和SCZ的共同遗传位置.
- 单变体和多变体MR证实,基因预测的抑郁症 (OR 1.270) 和SCZ (OR 1.047) 与AAA风险增加有关.
结论:
- 基因预测抑郁症和SCZ与患腹主动脉动脉瘤 (AAA) 的风险更高有关.
- 传统的AAA风险因素,包括吸烟,高血压和高脂血症,调解了抑郁症和SCZ与AAA之间的关系.
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