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主要容器系统的离心机化

Brian Wong¹, Kaitlin Wang¹, Kavin Kowsari¹

¹Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., Rahway, NJ 07065, United States.

Journal of pharmaceutical sciences

|February 1, 2025

概括

一种新的方法使用常见的离心机在预装注射器 (PFS) 中创建统一的油层. 这种技术改善了滑,克服了当前工业油涂层工艺的局限性.

科学领域:

制药技术制药技术制药技术
材料科学是一种材料科学.

背景情况:

预装注射器 (PFS) 需要油滑,以使子移动.
目前的油涂层方法产生不均的层,并使用专门的设备.

研究的目的:

开发一种可访问和有效的方法,用于在PFS中创建统一的油层.
解决现有的油涂层技术的局限性.

主要方法:

一种使用标准离心机技术的新油涂层技术.
可调节层厚度 (400-1800nm) 通过调整离心机速度和温度来实现.

主要成果:

在PFS中产生均的油层.
通过调整工艺参数来证明对层厚度的控制.
克服了传统方法中常见的地形缺陷,如沟.

结论:

开发的以离心机为基础的方法为PFS的油涂层提供了优质的替代方案.
这种可访问的技术增强了注射器的功能和统一性.
在研究和非商业环境中更广泛采用的潜力.

关键词:

离心机离心机离心机的使用方法油分销公司化是一种化.化过程中的化过程.注射器的功能的功能.预装注射器 (PFS) 是一个预装注射器.

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