药理动力学和药理动力学方法,以优化新生儿抗生素的使用
Sarah A Coggins1, Rachel G Greenberg2
1Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Neonatology (2 Main NW), Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Clinics in perinatology
|February 1, 2025
概括
优化新生儿,特别是早产婴儿的抗生素剂量是复杂的,因为独特的生理学和有限的数据. 本综述探讨了药理动力学 (PK) 和药理动力学 (PD),以指导更好的新生儿抗生素治疗.
科学领域:
- 新生儿药理学 新生儿药理学
- 传染病管理 传染病管理
- 儿科药物开发 儿科药物开发
背景情况:
- 新生儿,特别是早产婴儿,经常接受实证抗生素,使它们在新生儿重症监护病房中很常见.
- 优化新生儿抗生素剂量面临挑战,包括研究设计障碍,与成人/儿科生理差异以及缺乏特定的药理动力学目标.
- 对于新生儿抗生素剂量的现有药理动力学 (PK) 和药理动力学 (PD) 数据正在发展.
研究的目的:
- 审查新生儿的药理动力学 (PK) 和药理动力学 (PD) 的基本概念.
- 描述用于新生儿群体当前PK/PD分析中的药量计策略.
- 检查影响新生儿三种常见抗生素剂量的PK/PD数据的进展.
主要方法:
- 文献综述侧重于PK/PD原则及其在新生儿抗生素研究中的应用.
- 在当代新生儿PK/PD研究中使用的药量计方法的分析.
- 对精选的新生儿抗生素进行历史和当前PK/PD数据的综合.
主要成果:
- 该审查涵盖了与新生儿药物处置和作用相关的基本PK/PD概念.
- 它详细介绍了用于新生儿抗生素剂量的各种药理测量技术.
- 介绍了三种经常使用的新生儿抗生素PK/PD数据的演变.
结论:
- 了解新生儿生理学对于有效的抗生素剂量至关重要.
- 药量计策略对于分析复杂的新生儿PK/PD数据至关重要.
- 持续的研究和数据演变是必要的,以完善新生儿的抗生素治疗.
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