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Updated: May 29, 2025

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
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中枢神经系统分布动力学 选择的基因素脱乙酶抑制剂的分布动力学

Wenqiu Zhang1, Ju-Hee Oh1, Wenjuan Zhang1

  • 1Department of Pharmaceutics, Brain Barriers Research Center, University of Minnesota, Minneapolis, Minnesota.

The Journal of pharmacology and experimental therapeutics
|February 1, 2025
PubMed
概括

像伏利诺斯塔特和奎西诺斯塔特这样的基因组脱乙酶抑制剂 (HDACIs) 由于快速降解和中枢神经系统暴露不足,显示出有限的脑瘤疗效. 了解它们的药理动力学对于优化脑癌治疗策略至关重要.

关键词:
血液-大脑屏障是什么?癌症化疗 癌症化疗药理动力学 药理动力学

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