机械去除斑块的体外模拟方法:对当前技术和未来方向的系统范围审查
Johannes Herzog1, Jelena Karacic1, Leonardo Svellenti1
1Department of Periodontology, Endodontology and Cariology, University Center for Dental Medicine Basel UZB, University of Basel, 4058, Basel, Switzerland.
BMC oral health
|February 1, 2025
概括
目前在实验室环境中模拟口腔斑块的方法是不够的. 这次审查发现,没有一种单一的方法能够有效地复制斑块的特征,这凸显了需要改进的体外模型来测试口腔卫生功效的必要性.
科学领域:
- 牙科研究 牙科研究
- 生物材料科学 生物材料科学
- 口腔健康 口腔健康
背景情况:
- 开发有效的口腔卫生产品需要精确的牙斑在体外模型.
- 现有的模拟方法在复制斑块复杂性质的能力上有所不同.
研究的目的:
- 对模拟口腔斑块的现有方法进行范围审查.
- 评估当前斑块模拟技术的好处和局限性.
主要方法:
- 在PubMed和Scopus数据库中进行系统的文献搜索,截至2024年7月.
- 选标题和摘要,然后对检索的研究进行全文审查.
- 基于九个定义的特征进行数据提取和评估,用于斑块模拟.
主要成果:
- 包括25篇描述七种不同斑块模拟方法的全文文章.
- 评估的方法包括墨水,漆,酸,碳酸,闭口喷雾,和人造斑块.
- 没有一个模拟方法获得总体"好"或"非常好"的评分;油墨和漆是中等的,其他是弱的.
结论:
- 目前的体外斑块模拟方法无法充分复制口腔斑块的基本特征.
- 一些方法可能有助于单独评估特定的斑块特性.
- 需要先进的模型来更全面地反映牙斑块的各种特征.
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