升高的囊素C水平与阻塞性睡眠呼吸暂停症候群之间的关联:系统性审查和更新的元分析
Nianying Fu1, Xiaotao Tan2, Jie He3,4,5
1Pulmonology Department, Guanghan Hospital of Traditional Chinese Medicine, DeYang, Sichuan, China.
BMC pulmonary medicine
|February 1, 2025
概括
升高的囊素C水平与阻塞性睡眠呼吸暂停性呼吸暂停综合征 (OSAHS) 有关,并增加中风和心血管事件的风险. 持续的正气道压力 (CPAP) 治疗可以降低这些水平,表明囊素C.
科学领域:
- 生物标志物在睡眠医学中的作用
- 心血管和脑血管健康
- 代谢和内分泌疾病 代谢和内分泌疾病
背景情况:
- 阻塞性睡眠呼吸暂停症候群 (OSAHS) 与心血管和脑血管风险的增加有关.
- 囊素C是功能和炎症的标志物,已成为各种疾病的潜在生物标志物.
研究的目的:
- 为了比较OSAHS患者和对照者的cystatin C水平.
- 调查囊素C与OSAHS心血管/脑血管并发症之间的关联.
- 为了评估手术或CPAP对OSAHS患者的cystatin C水平的影响.
主要方法:
- 在主要数据库 (PubMed, CNKI, EMBASE, Web of Science, WanFang) 进行系统的文献搜索,直到2024年10月.
- 40项使用标准化平均差异 (SMD) 和相关系数 (COR) 的研究的元分析.
- 基于异质性的固定效应或随机效应模型被使用 (I2).
主要成果:
- 与对照组相比,患有OSAHS的患者的血清/血囊C水平显著更高 (SMD = 0.65).
- 升高的囊素C水平与AHI和ODI正相关,并被确定为中风和MACC的危险因素.
- 在OSAHS患者中,CPAP治疗显著降低了囊素C水平.
结论:
- 在OSAHS患者中,高氨酸C是心血管和脑血管疾病的潜在危险因素.
- 赛斯塔丁C可以作为一个有价值的临床指标来评估OSAHS的严重程度和治疗疗效.
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