生命的基本8和帕金森病之间的关联:一个病例控制研究
Jiaxin Fan1,2,3, Yanfeng Wang4,5, Xingzhi Guo1,2,6
1Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No. 256 West Youyi Road, Xi'an, 710068, China.
BMC public health
|February 1, 2025
概括
通过Life's Essential 8 (LE8) 度量衡量的较高的心血管健康 (CVH) 与帕金森病 (PD) 的风险降低有关. 这种关联在女性中更为显著,这表明了潜在的性别特异性预防策略.
科学领域:
- 心血管健康和神经病学
- 公共卫生和流行病学
背景情况:
- 心血管健康 (CVH) 对于整体健康至关重要.
- 生活必需品8 (LE8) 指标提供了对CVH的全面评估.
- LE8指标与帕金森病 (PD) 风险之间的关系仍然未得到充分探索.
研究的目的:
- 调查生命的基本8 (LE8) 指标与美国成年人中帕金森病 (PD) 的患病率之间的联系.
- 探索该协会中潜在的性别差异.
主要方法:
- 利用了2005-2018年国家健康和营养检查调查 (NHANES) 的26,975名参与者的数据.
- 根据美国心脏协会的标准计算了LE8指标,并使用多变量逻辑回归分析了它们与PD的关联.
- 采用灵敏度分析,受限立方线分析 (RCS) 和子组分析来验证发现并探索非线性关系和相互作用.
主要成果:
- 在连续的LE8指标和PD风险 (OR=0.97,P<0.01) 之间发现了显著的反向关联.
- 高LE8指标组的参与者与低LE8指标组相比,患PD的几率要低得多 (OR=0.51,P<0.01).
- 观察到非线性关系,女性与男性相比,这种关联更强 (P相互作用=0.029).
结论:
- 根据LE8指标的指标,改善心血管健康与降低患帕金森病的风险有关,这种风险以剂量-反应的方式.
- 针对PD的LE8指标的保护作用在女性中更为明显.
- 这些发现表明,LE8指标可以为PD预防和管理提供有针对性的,性别特定的策略.
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