用复合激活因子VII控制严重登革热严重危及生命的出血
1Director and Head, Department of Internal Medicine, Fortis Escorts Hospital, Jaipur, Rajasthan, India, Orcid: https://orcid.org/0000-0001-6449-3914, Corresponding Author.
The Journal of the Association of Physicians of India
|February 2, 2025
概括
严重的登革热可能导致危及生命的出血. 重组激活因子VII (rFVIIa) 在患有严重登革热的患者中有效停止出血,稳定血红蛋白,没有并发症.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 严重的登革热 (DF) 是一种严重的疾病,与严重的出血风险有关.
- 在DF患者中管理危及生命的出血 presents实质性的临床挑战.
研究的目的:
- 报告一个严重的登革热病例与危及生命的出血.
- 评估复合激活因子VII (rFVIIa) 的疗效和安全性,用于治疗严重DF的耐火性出血.
主要方法:
- 一个严重的登革热患者的病例报告,出现了自发的,胃肠道和肺部出血.
- 在广泛的血液产品输血失败后,给予一次静脉注射rFVIIa (6mg) 剂量.
- 监测血静控制和血栓栓塞并发症.
主要成果:
- 患者经历了严重的多部位出血,需要在48小时内服用39单位血液制品.
- 在rFVIIa给药后,活跃出血停止,血红蛋白水平稳定.
- 在治疗后没有观察到任何不良的血栓栓塞事件.
结论:
- rFVIIa在严重登革热患者中实现静血的有效性被证明是具有难以治疗的出血.
- rFVIIa可能是一个有价值的治疗选择,选择严重的DF患者耐受常规管理.
- 需要进一步的研究来确定rFVIIa在严重登革热管理中的作用和安全性.
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