相关实验视频
Updated: Jun 18, 2026

06:46
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
杆菌,逆流和慢性鼻炎之间的关联:系统性审查
Jerome R Lechien1,2,3,4, Kamal Ragrag5, Jason Kasongo5
1Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. Jerome.Lechien@umons.ac.be.
概括
黑杆菌 (HP) 在慢性鼻炎 (CRS) 患者的三分之一鼻腔组织中发现,可能表明GERD. 它在CRS开发中的作用需要进一步研究,因为研究的不一致性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 慢性鼻炎 (CRS) 患者的鼻腔组织中Helicobacter Pylori (HP) 的存在和意义尚未得到充分证实.
- 了解HP的作用对于管理CRS至关重要,特别是在有鼻息肉 (CRSwNP) 和没有鼻息肉 (CRSsNP) 的情况下.
研究的目的:
- 确定CRS患者中HP的患病率和临床相关性,区分CRSwNP和CRSsNP.
- 评估在鼻腔组织中HP检测与胃食道逆流病 (GERD) 等临床因素之间的关联.
主要方法:
- 使用PRISMA指南进行了系统审查和元分析,搜索了PubMed,Scopus和Cochrane图书馆.
- 包括的研究分析了使用PCR,IHC和ELISA等方法在CRS患者 (n=741) 和对照组 (n=368) 中的HP患病率.
- 进行偏差和异质性分析以评估研究质量和一致性.
主要成果:
- 在37.1%的CRSwNP多体 (PCR) 和32.7% (IHC) 中检测到HP,而对照组中则为14.8% (PCR) 和3.6% (IHC).
- 在CRSwNP和CRSsNP之间没有发现HP率的显著差异.
- 鼻组织中HP检测与GERD严重程度相关,血液HP抗原在48.7%的CRS患者中被检测到,而对照组为41.6%.
结论:
- 球杆菌可检测到大约三分之一的CRS患者的鼻腔组织.
- 在CRS患者中,HP可作为GERD的生物标志物.
- 由于研究之间存在显著的异质性,HP在CRS病变发生过程中的直接作用仍然不确定.
相关概念视频
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
272
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
272
Chronic Pharyngitis
523
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
523
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
132
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
132
Gastroesophageal Reflux Disease II: Clinical Features and Management
31
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
31
Gastritis-II: Pathophysiology
160
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
160
Peptic Ulcer Disease I: Introduction
81
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
81

