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与帕金森病认知障碍相关的声学prosodic参数

Ye Liu¹, Xi-Xi Wang¹, Xu-Jun Wang²

¹Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.

Parkinsonism & related disorders

|February 2, 2025

概括

声学分析可以检测帕金森病 (PD) 患者的认知障碍. 语音模式,如速度和暂停,有助于区分正常认知,轻度认知障碍 (PD-MCI) 和痴呆症 (PDD).

科学领域:

神经学神经学
语音语言病理学语言病理学
生物医学声学生物医学声学

背景情况:

声学前分析显示,在阿尔茨海默病 (AD) 中识别轻度认知障碍 (MCI) 和痴呆症具有前途.
该研究假设声学分析也可以在帕金森病 (PD) 中区分认知障碍.

研究的目的:

调查声学参数在区分帕金森病 (PD) 认知障碍中的有用性.
评估声学参数对识别认知障碍PD的重要性和临床影响.

主要方法:

研究了90名受试者的声学参数:30名PD具有正常认知 (PD-NC),30名PD具有轻度认知障碍 (PD-MCI) 和30名PD患有痴呆症 (PDD).
使用阅读 ("超市通道") 和图片描述 ("饼干盗窃") 任务.
执行特征选择和建模,以评估声学参数在识别认知障碍中的作用.

主要成果:

声学参数与认知障碍 (PDD和PD-MCI) 独立相关,检测的AUC为0.826.
在"偷饼干"任务中,语音速度,动词前暂停 (≥1s) 和发言间暂停 (≥2s) 是关键因素.
特征选择显示,从PD-NC区分PDD (0.944) 和PD-MCI (0.753) 的AUC很高.

结论:

声学参数有效地区分PD患者与认知障碍与那些正常认知,独立于年龄.
声学参数显示了PD患者认知衰退风险自动查的潜力.
需要对PD认知评估的声学分析进行进一步的研究.

关键词:

声学参数声学参数认知障碍认知障碍是一种认知障碍.早期诊断早期诊断早期诊断帕金森病的疾病.这就是 Prosody 的意思.

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