饮食习惯和自然更年期的年龄之间的因果关系:一项两样饮食范围内的门德尔随机化研究
Chung-Chih Liao1, Chun-I Lee2, Jung-Miao Li3
1Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan; Department of Post-Baccalaureate Veterinary Medicine, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.
European journal of obstetrics, gynecology, and reproductive biology
|February 2, 2025
概括
某些饮食习惯可能会影响更年期的时间. 酒,酒和面包的消费与更早的更年期有关,而油性鱼则表明更晚的开始. 需要进一步的研究.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 更年期标志着一个重要的生命阶段,具有多样化的健康影响.
- 之前关于饮食和自然更年期 (ANM) 的观察性研究产生了不一致的结果.
- 由于混因素,饮食习惯和ANM之间的因果关系尚不清楚.
研究的目的:
- 研究各种饮食习惯与自然更年期 (ANM) 的年龄之间的因果关系.
- 为了利用两样饮食范围内的门德尔随机化 (MR) 方法来进行强大的因果推断.
主要方法:
- 利用来自英国生物银行和ReproGen联盟的大规模遗传和健康数据.
- 采用孟德尔的随机化 (MR) 用38种饮食习惯作为暴露和ANM作为结果.
- 应用多种MR方法 (IVW,MR-Egger,加权中位数) 和严格的灵敏度分析.
主要成果:
- 发现酒/酒消费和面包消费的传播与早期的ANM之间存在显著的关联.
- 观察到油性鱼类消费与后来的ANM之间存在潜在的关联,尽管经校正后在统计学上并不显著.
- 敏感性分析证实了所确定的关联的稳定性和可靠性,没有检测到显著的类型.
结论:
- 提供证据表明,特定的饮食模式可以因果关系地影响自然更年期的时间.
- 强调饮食在生殖衰老中的关键作用.
- 表明需要进一步研究这些饮食和更年期关联背后的机制.
相关概念视频
01:28Menopause
129
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
129
01:20Study Designs in Epidemiology
171
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
171
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
02:20Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
03:09Meiosis I
37.7K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
37.7K
02:07Oogenesis
63.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.4K