氧化沉积与结石病的风险增加有关:一个队列研究
Mahum Mirza1, Alison Fernandes1, Katherine Sherman1
1From: The Division of Rheumatology, Medical College of Wisconsin, and the Zablocki VA Medical Center, Milwaukee, WI, United States.
Seminars in arthritis and rheumatism
|February 2, 2025
概括
患有酸沉积疾病 (CPPD) 的患者患结石 (结石) 的患病率显著更高. 这表明CPPD可能是一种系统性矿化障碍,影响关节以外的器官.
科学领域:
- 类风湿病学 类风湿病学
- 腎臟病學 (nephrology) 是一種醫學.
- 矿化障碍 矿化障碍 矿化障碍
背景情况:
- 酸盐沉积疾病 (CPPD) 是一种影响老年人的关节炎,其特征是关节炎.
- 虽然CPPD的确切原因尚不清楚,但它可能与其他影响矿物代谢的疾病有关.
- 新出现的证据表明,CPPD与系统性矿物化问题之间存在潜在的联系.
研究的目的:
- 为了调查CPPD患者患有结石 (结石) 的患病率增加的假设.
- 为了确定CPPD是否是结石病的独立风险因素.
主要方法:
- 使用国家VA企业数据仓库进行的回顾性队列研究.
- 鉴定了18761名CPPD患者 (2010-2014) 并将他们与75,043名对照进行了匹配.
- 评估和比较了结石病的患病率,并调整了诸如甲状腺功能障碍症等危险因素.
主要成果:
- 与对照组 (5.1%) 相比,CPPD患者中结石病的患病率明显高 (8.6%).
- 对于CPPD患者,结石病的调整后几率比为1.659.
- 即使排除了患有甲状腺功能障碍症的患者,这种关联仍然很重要.
结论:
- CPPD是结石形成的独立风险因素.
- 这些发现支持CPPD作为一种系统性矿化障碍的观点,其影响超出了关节疾病.
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