基于人工智能的急性呼吸衰竭在急诊室的早期预测,使用生物信号和临床数据
Changho Han1, Yun Jung Jung2, Ji Eun Park2
1Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea.
Yonsei medical journal
|February 2, 2025
概括
分析生物信号的人工智能 (AI) 模型可以预测急性呼吸衰竭 (ARF) 在急诊室. 这种人工智能方法对早期检测和改进的患者分拣有很大的希望,其表现优于传统的评分系统.
科学领域:
- 生物医学工程 生物医学工程
- 人工智能在医学中的应用
- 临界护理医学 临界护理医学
背景情况:
- 早期识别急性呼吸衰竭 (ARF) 风险患者对于实施预防策略至关重要.
- 使用人工智能 (AI) 分析复杂的生物信号数据可以揭示细微的模式,表明患者的病情恶化.
- 高分辨率生物信号为先进的预测建模提供丰富的时间信息.
研究的目的:
- 开发和验证能够在急诊室入院72小时内预测ARF的AI模型.
- 为了利用在抵达前4小时内收集的高分辨率生物信号,进行ARF预测.
- 评估人工智能模型的性能与已建立的临床评分系统相比.
主要方法:
- 开发一个卷积循环神经网络 (CRNN) 模型,集成生物信号特征提取和序列建模.
- 内部验证使用5284名患者入院的数据,其中20.5%被诊断为ARF.
- 外部验证对144例入院的单独队列进行验证,其中4.9%的患者患有ARF,定义为需要先进的呼吸辅助.
主要成果:
- 人工智能模型实现了接收器操作特征曲线 (AUROC) 下的面积为0.840 (内部) 和0.743 (外部验证).
- 与仅使用临床变量的修改早期预警分数 (MEWS) 和XGBoost模型相比,人工智能模型表现出优异的预测性能.
- 观察到显著的死亡预测能力 (AUROC高达0.809),AI得分增加与更高的ARF和死亡风险相关.
结论:
- 开发的AI模型在预测ARF方面具有很高的准确性,并且与临床结果密切相关.
- 人工智能模型显示了在急诊室内临床分拣决策中立即应用的潜力.
- 利用人工智能进行生物信号分析,在疾病检测和患者风险分层方面取得了重大进展.
更多相关视频
06:37Author Spotlight: Addressing Technical and Subjective Challenges in Measuring Classroom Attention
Published on: December 15, 2023
2.6K
06:22Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
3.3K
相关概念视频
Acute Respiratory Failure-V
121
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
121
Acute Respiratory Failure-IV
120
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
120
Acute Respiratory Failure-I
162
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
162
Respiratory Assessment: Purpose and Indications
1.0K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.0K
Acute Respiratory Failure-III
153
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
153
Acute Respiratory Failure-II
164
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
164
