性少数群体的压力和表观遗传衰老
Lisa M Christian1, Stephanie Wilson2, Annelise A Madison3
1Department of Psychiatry & Behavioral Health, The Ohio State University Wexner Medical Center Columbus OH USA; The Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center Columbus OH USA.
Brain, behavior, and immunity
|February 2, 2025
概括
双性恋女性表现出加速的生物衰老,内化同性消极性和反双性恋经历增加了这种风险. 更多的身份肯定和社会支持可能会减缓这一群体的衰老.
科学领域:
- 卫生科学 卫生科学 卫生科学
- 心理学 心理学 心理学
- 遗传学 遗传学 是一个
背景情况:
- 女同性恋,男同性恋,双性恋,跨性别者和酷尔/质疑 (LGBTQ+) 个人与异性恋者相比,体验的健康结果较差.
- 双性人经常面临比同性恋者更糟糕的健康状况.
- 关于压力生物学及其对性少数群体健康影响的数据严重缺乏.
研究的目的:
- 为了研究双性恋女性的生物衰老标志物.
- 探索双性恋女性心理社会因素和生物衰老之间的关系.
- 为了确定这个人口中加速衰老的潜在风险和保护因素.
主要方法:
- 利用了来自国家夫妇健康和时间研究的32名双性恋女性的数据.
- 通过使用DNA甲基化数据 (DunedinPACE,GrimAge2) 评估生物衰老.
- 分析了内部化的同性消极性,反双性经验,身份肯定,社会支持和表观遗传年龄加速之间的关联.
主要成果:
- 研究中的双性恋女性与他们的时间年龄相比,表现出显著加快的表观遗传衰老 (13%更快的DunedinPACE,8.67岁更老的GrimAge2).
- 更高的内化同性消极性和更频繁的反双性经验与更大的表观遗传年龄加速有关.
- 更强大的身份中心性,身份肯定和朋友支持与更慢的表观遗传衰老有关.
结论:
- 双性恋女性面临着加速生物衰老的风险.
- 心理社会压力因素,包括内化同负性和歧视,可能会导致这种加快的衰老.
- 社会和身份肯定似乎是对双性恋女性加快衰老的保护因素.
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