加载奎尔的固体脂质纳米颗粒增强了抗虫活动.
Sunidhi Sharma1, Ruchika Thukral2, Lachhman Das Singla3
1Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala 147004, Punjab, India.
International journal of pharmaceutics
|February 2, 2025
概括
这项研究开发了含有素的固体脂质纳米粒子 (SLN-Qt),以提高口服生物可用性和有效性. 在没有观察到毒性的老鼠中,SLN-Qt显著减少了寄生虫感染,提供了一个有前途的药物输送策略.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术 纳米技术
- 寄生虫学的寄生虫学
背景情况:
- 奎尔塞丁是一种黄类化合物,具有抗致癌,抗病毒和抗炎性质.
- 由于肠道新陈代谢,口服生物可用性较差限制了奎尔塞丁的治疗效果.
- 基于脂质的纳米颗粒提供了一种策略,可以提高难溶性药物的可溶性和输送.
研究的目的:
- 开发和表征素载固体脂质纳米颗粒 (SLN-Qt) 以改善口服.
- 评估SLN-Qt.的体外药物释放特征.
- 评估SLN-Qt在感染大鼠中的体内抗虫疗效和安全性.
主要方法:
- 球形,水溶性固体脂质纳米粒子 (SLN-Qt) 的制造和表征.
- 在pH 6.4和pH 7.4.4的情况下进行体外药物释放研究.
- 在各种胃肠道虫感染的老鼠体内抗虫疗效测试.
- 评估肝脏组织学和生物化学参数的毒性.
主要成果:
- SLN-Qt的水力动力学尺寸为130.7 ± 42.0 nm,药物捕获效率为79.75%.
- 观察到药物持续释放,在24小时内释放37.5% (pH6.4) 和6天内释放93.7% (pH7.4).
- SLN-Qt治疗 (200 mg/Kg) 显著降低了寄生虫卵数量85.09%,并且在老鼠中没有显示出毒性.
结论:
- 通过SLN-Qt增强了可溶性和生物可用性,可用于口服.
- 这种配方在体内显示出对胃肠道虫的显著疗效.
- SLN-Qt代表了一种有前途的纳米载体,用于治疗寄生虫感染和输送难溶药物.
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