相关实验视频
Updated: May 29, 2025

09:27
Protein Crystallization for X-ray Crystallography
Published on: January 16, 2011
63.3K
重新审视肌酸酸的固态景观:盐还是共晶?
Gregory York1, Andrew W Kelly1, Lee Robison1
1Analytical Research & Development, Merck & Co., Inc., Rahway, NJ 07065, United States.
Journal of pharmaceutical sciences
|February 2, 2025
概括
研究人员探索了肌酸和酸的固体形式. 他们发现了一种新的,热力学稳定的1:1共晶体,澄清了先前在肌酸联合配方研究中的差异.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 固态化学 固态化学
背景情况:
- 肌酸是一种受欢迎的运动补充剂,溶解性差,导致各种配方.
- 肌酸和酸的共同配制产生了盐和共晶,形成偏好不明.
- 肌酸的zwitterionic性质使得对盐与共晶形成的理解变得复杂.
研究的目的:
- 解决有关肌酸-酸固体形式的文献中的差异.
- 为了研究肌酸-酸共同配方的固态景观.
- 为了确定肌酸和酸之间的热力学偏好的固体形式.
主要方法:
- 合成了一种新的1:1肌酸-酸联合晶体.
- 计算自由能量以确定热力学稳定性.
- 对之前报告的盐和共晶形成方法的分析.
- 用X射线衍射,热分析和红外光谱来进行表征.
- 计算预测和晶体结构分析.
主要成果:
- 一个新的1:1肌酸-酸共晶成功合成.
- 自由能量计算证实了新同晶体对现有形式的热力学偏好.
- 结晶结构分析显示zwitterionic肌酸与中性酸相互作用.
- 实验和计算数据支持新晶的热力学优势.
结论:
- 该研究发现了一种新的,热力学稳定的1:1肌酸-酸共晶.
- 这一发现澄清了肌酸-酸共同配方的固态行为.
- 了解这些相互作用对于优化肌酸补充剂配方和生物可用性至关重要.
相关概念视频
Precipitation Reactions
50.0K
In a precipitation reaction, aqueous solutions of soluble salts react to give an insoluble ionic compound – the precipitate. The reaction occurs when oppositely charged ions in solution overcome their attraction for water and bind to each other, forming a precipitate that separates out from the solution. Since such reactions involve the exchange of ions between ionic compounds in aqueous solution, they are also referred to as double displacement, double replacement, exchange reactions, or...
50.0K
Ions as Acids and Bases
23.3K
Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
23.3K
Ionic Strength: Effects on Chemical Equilibria
1.3K
The addition of an inert ionic compound increases the solubility of a sparingly soluble salt. For example, adding potassium nitrate to a saturated solution of calcium sulfate significantly enhances the solubility of calcium sulfate. Le Châtelier's principle cannot predict this shift in the equilibrium. Instead, this could be explained in terms of changes in the effective concentration of the ions in solution in the presence of added inert salt.
In this solution, the primary...
In this solution, the primary...
1.3K
Molecular and Ionic Solids
16.8K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
16.8K
Recrystallization: Solid–Solution Equilibria
1.0K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
1.0K
Ionic Crystal Structures
14.1K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
14.1K

