心血管风险因素与年轻成年人的脑血管反应性有关
Jaskanwal D S Sara1, Jay J Pillai2, Lilach O Lerman3
1Department of Cardiovascular Medicine, Mayo College of Medicine, Rochester, MN, USA.
International journal of cardiology
|February 2, 2025
概括
传统的心血管风险因素,如年龄,高血压和高脂血症,与未患有心血管疾病 (CVD) 的年轻人脑血管反应率 (CVR) 的降低有关. 这一发现突显了年轻人群体血管健康的早期指标.
科学领域:
- 神经成像是一种神经成像.
- 心血管科学 心血管科学
- 血管生物学 血管生物学
背景情况:
- 内皮功能障碍是动脉样硬化最早的迹象,预测心血管事件和心血管疾病 (CVD) 风险.
- 脑血管反应率 (CVR) 测量大脑内皮功能,与中风,痴呆和冠状动脉疾病有关.
- 虽然传统的心血管疾病风险因素与老年人心血管回血率低有关,但它们对没有心血管疾病的年轻人心血管回血率的影响尚不清楚.
研究的目的:
- 为了研究心血管风险因素与年轻成年人没有先前存在心血管疾病的降低心血管风险之间的关联.
- 测试假设,心血管风险因子增加与接受临床fMRI的年轻成年人中较低的CVR相关.
主要方法:
- 一项横截面研究分析了76名患有的成年人,这些成年人接受了3-Tesla fMRI,使用了喘息任务.
- 来自fMRI的大脑T统计数据被用于评估全球CVR,将参与者分为高 (正常) 和低 (异常) 反应率组.
- 临床数据,包括心血管风险因素,被追溯审查和CVR组之间的比较.
主要成果:
- 与正常CVR患者相比,异常CVR患者 (n=44) 年龄较大,患高血压和高脂血的频率较高.
- 异常的CVR与年龄较大,较高的静缩和腹缩血压以及高脂血症显著相关.
- 多变量分析证实,年龄,缩血压和高脂血症独立地与心脏回血率降低有关.
结论:
- 传统的心血管风险因素,包括年龄,缩血压和高脂血症,与年轻成年人的异常心血管回路显著相关.
- 这些发现表明,即使在没有被诊断为心血管疾病的年轻人中,心血管风险因素也可能影响脑血管健康.
- 这项研究强调了监测年轻成年人的CVR的重要性,因为这可能是亚临床血管变化的潜在指标.
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