针对两种类型的肠道病毒71疫苗的免疫监测后的不良事件:在中国进行的一项真实世界的比较研究
Yiqing Zhu1, Yihan Wang1, Jinghui Wang1
1Department of Immunization Management, Hebei Province Center for Disease Prevention and Control, Shijiazhuang, Hebei Province, China.
Human vaccines & immunotherapeutics
|February 2, 2025
概括
两种类型的肠道病毒71 (EV71) 疫苗,EV71-Vero和EV71-H2,显示出良好的安全性. 免疫接种后的不良事件 (AEFI) 类似,尽管在AEFI中注意到与年龄相关的差异.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 肠道病毒71 (EV71) 感染对儿童健康构成重大威胁.
- 目前有两种不同的EV71疫苗,即EV71-Vero (Vero细胞) 和EV71-H2 (人类双胞胎细胞).
- 全面的安全数据对于疫苗推和公共卫生政策至关重要.
研究的目的:
- 为了比较EV71-Vero和EV71-H2疫苗免疫接种后的安全性和不良事件 (AEFI).
- 在河北省接种疫苗的儿童中分析不同年龄组的AEFI率和特征.
- 为EV71疫苗使用提供基于证据的建议.
主要方法:
- 从2019年至2023年接种EV71-Vero或EV71-H2的儿童的AEFI数据的回顾性分析.
- 两个疫苗组之间的AEFI发病率和类型的比较.
- 统计分析以确定AEFI在人口统计学变量,特别是年龄方面的显著差异.
主要成果:
- 报告共有477种AEFI,总量为每10万剂量14.21.
- 大多数AEFI发生在1岁以下的婴儿身上 (45.91%).
- 在EV71-Vero和EV71-H2疫苗之间的AEFI率没有显著的总体差异,但观察到特定年龄的变化,特别是在1岁以下的儿童和4-5岁的儿童中.
结论:
- 两种EV71-Vero和EV71-H2疫苗都显示出良好的安全性.
- 虽然AEFI总体比率是可比的,但特定年龄的监测和分析很重要.
- 建议在适当的年龄组接种EV71疫苗,以预防EV71感染.
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