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一个罕见的Interleukin-6产生的上皮上腺癌病例,伴随着持续的发烧
Kohei Oguni1,2, Yukiko Goshima1, Keita Tatsushima1
1Department of Endocrinology and Metabolism, Toranomon Hospital, Japan.
Internal medicine (Tokyo, Japan)
|February 2, 2025
概括
一个罕见的上腺皮质癌 (ACC) 病例被确定,该病例表现为青少年持续发烧. 瘤产生了白血素-6 (IL-6),在手术切除后消失,突出了长期发烧的新原因.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 儿科医学 儿科医学
背景情况:
- 青少年的持续发烧可能源于各种原因,包括罕见的恶性瘤.
- 上皮层癌 (ACC) 是一种罕见的上腺瘤,具有不同的临床表现.
- 干乐素-6 (IL-6) 是一种促炎性细胞因子,与发烧病原发生有关.
研究的目的:
- 报告第一个具有症状的IL-6产生的上腺皮质癌 (ACC) 病例.
- 描述儿童患者这种罕见疾病的临床表现,诊断和管理.
主要方法:
- 一个16岁的女性长期发烧的案例介绍.
- 诊断工作包括计算机断层扫描 (CT) 和实验室测试 (IL-6,C反应蛋白).
- 手术干预 (镜左上腺切除术) 和组织病理学分析 (韦斯得分,IL-6免疫活性).
主要成果:
- 在CT上确定了4厘米的左上腺质量.
- 观察到血清IL-6和C-反应蛋白水平显著升高.
- 上腺切除术后,发烧消失,IL-6水平正常化.
- 病理学证实了具有IL-6产生瘤细胞的ACC (韦斯评分5/9).
结论:
- 症状性IL-6产生ACC可以最初表现为持续发烧.
- 上腺切除术是一种有效的治疗IL-6介导的副瘤发烧在ACC.
- 这种病例扩大了已知的上腺皮层癌的临床谱.
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