在使用不同的诊断标准的三个澳大利亚样本中,认知"超级衰老"的频率不同
Alice Powell1, Ben C P Lam2, David Foxe3
1Centre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
International psychogeriatrics
|February 2, 2025
概括
澳大利亚老年人的认知超衰老频率根据定义有很大差异,但与更好的功能和更低的痴呆风险有关. 定义的标准化是描述这一特殊群体的关键.
科学领域:
- 老年学是一门学科.
- 认知神经科学 认知神经科学
- 流行病学 流行病学
背景情况:
- 异常认知,或认知超衰老,是老年人中的少数人.
- 了解超衰老的患病率和特征对于衰老研究至关重要.
研究的目的:
- 为了确定澳大利亚老年人认知超衰老的频率.
- 评估不同超老化定义之间的一致性.
- 探索超级衰老状态与功能,神经成像和痴呆症结果之间的关系.
主要方法:
- 分析了三项涉及老年人 (65-106岁) 没有痴呆症的纵向队列研究.
- 使用基于神经心理测试的九个不同的定义来评估超级衰老.
- 探索与功能表现,脑成像标志物和事件痴呆症的关联.
主要成果:
- 超衰老的频率在2.9%至43.4%之间,受定义严格性的影响.
- 定义之间的一致性从差到非常好各不相同.
- 超级衰老与功能改善,痴呆发病减少和较低的白质超强度负担有关.
结论:
- 认知超衰老的定义显著影响其观察到的频率.
- 为了准确的表征,需要在定义超级衰老方面更加一致.
- 超级衰老与积极的健康和认知衰老标志物有关.
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