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Updated: May 29, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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循环素依赖激酶4/6抑制剂相关的肺毒性:基于FAERS数据库的2015年至2023年的不成比例分析

Qian Cheng1, JunSheng Qi1, Shupeng Zou1

  • 1Department of pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Expert opinion on drug safety
|February 2, 2025
PubMed
概括

像abemaciclib和ribociclib这样的循环素依赖性激酶4/6抑制剂 (CDK4/6抑制剂) 与肺毒性有关,包括肺炎和. 这种风险在女性和老年患者中更高.

关键词:
循环素依赖性激酶4/6抑制剂公平的人是公平的.药物监督和药物监督肺炎是一种肺炎.肺部水腫 肺部水腫肺动脉血栓形成 肺动脉血栓形成

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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