相关实验视频

Updated: Jul 5, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

状细胞病患者甲状腺功能异常:一个元分析

Sagad O O Mohamed¹, Hussein Ahmed², Mohammed A H Mohammednoor²

¹Faculty of Medicine, University of Khartoum, Alqasr Avenue, P.O. Box 102, Khartoum, Sudan. s.oom123@yahoo.com.

Thyroid research

|February 2, 2025

概括

状细胞疾病 (SCD) 患者的甲状腺刺激激素 (TSH) 水平较高,甲状腺激素水平较低的趋势. 监测甲状腺功能对于在SCD中早期检测甲状腺功能低下至关重要.

科学领域:

内分泌学在内分泌学.
血液学血液学血液学
遗传学是一个遗传学.

背景情况:

内分泌功能障碍在状细胞疾病 (SCD) 中越来越多地被认可.
在SCD中甲状腺疾病可能导致生长和认知障碍.
在SCD中甲状腺异常程度的数据是有限的.

研究的目的:

系统地审查和分析SCD患者的甲状腺功能异常.
为了确定甲状腺疾病在SCD人群中的患病率和频谱.

主要方法:

在遵守PRISMA指南的基础上进行系统审查.
在主要的科学数据库 (Medline/PubMed,谷歌学者等) 进行的搜索. ) 的情况.
用于计算聚合流行率和标准化平均差异 (SMD) 的元分析.

主要成果:

包括19项研究;在SCD患者中发现血清TSH水平升高 (SMD = 1.184,p=0.011).
在SCD患者中观察到较低T3,T4,自由T3和自由T4水平的趋势.
在SCD中,甲状腺功能低下症的综合患病率为4.9%,亚临床甲状腺功能低下症为8.7%.

结论:

SCD患者往往具有提升的TSH水平,表明潜在的甲状腺功能障碍.
亚临床甲状腺功能低下症存在于SCD患者的一个子集中.
在SCD管理中,定期监测甲状腺功能至关重要,以防止明显的甲状腺功能低下和不良结果.

关键词:

甲状腺功能低下症甲状腺功能低下症进行元分析分析.状细胞疾病是一种状细胞疾病.甲状腺是什么?甲状腺是什么?

更多相关视频

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

相关概念视频

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...