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Xuanyi Jin^1,2, Wan Ting Tay¹, Dinna Soon³

¹National Heart Centre Singapore, Singapore, Singapore.

Cardiovascular ultrasound

|February 2, 2025

概括

患有心力衰竭 (HF) 的患者可以有不同的左心房 (LA) 和左心室 (LV) 功能障碍模式. 在HF中占主导地位的LA肌病与老年,心房动,糖尿病和较低的生存率有关.

科学领域:

心脏病学心脏病学
心血管成像 - 心血管成像
心脏衰竭病理生理学病理生理学

背景情况:

左心房 (LA) 和左心室 (LV) 功能障碍在心力衰竭 (HF) 患者中经常并存.
一些HF患者表现出不成比例的LA或LV功能障碍,称为肌肉病变.
描述这些不同的肌肉病变对于理解HF异质性至关重要.

研究的目的:

为了表征患有主导LA和LV肌病症的患者.
为了分析慢性HF患者的队列,在LV射出分数 (LVEF) 的整个频谱中.
为了确定不同LA/LV肌病模式的HF患者群体之间的临床和生物标志物差异.

主要方法:

利用了全国范围的,前性的,多中心的观测HF队列.
进行了2D斑点跟踪分析的横体心电回声学.
测量LA储菌株和LV全球纵向菌株 (LVGLS) 来定义肌肉病.

主要成果:

从374名HF患者中,确定了47名患有主导LA肌病,271名患有平衡LA/LV,56名患有主导LV肌病.
主要的LA肌病患者年龄较大,心房动率较高,糖尿病,NT-proBNP,GDF15,hs-TNT升高,心房功能较差.
主导LA肌病的独立预测因素包括AF,糖尿病和更高的GDF15;没有糖尿病预测了主导LV肌病.
主要的LA肌病与较低的生存概率相关 (Log排名p=0.01).

结论:

大多数HF患者表现出平衡的LA/LV肌病.
在HF中占主导地位的LA肌病与年龄较大,AF和糖尿病等并发症以及心脏应激/损伤生物标志物的增加有关.
与平衡或主导的LV肌病相比,患有LA肌病的主导的患者面临更糟糕的临床结果.

关键词:

心脏衰竭是因为心脏衰竭.这是一种LV骨髓病变 (LV myopathy).这是一个LVEF.主要的是LA肌病症.

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