相关实验视频

Updated: May 29, 2025

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

菌株突变菌 (Streptococcus mutans) 和下:一个系统审查和元分析

D Mazurel¹, B W Brandt¹, M Boomsma¹

¹Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands.

Journal of dental research

|February 3, 2025

概括

这一审查证实Streptococcus mutans (S. mutans) 与空洞密切相关. 微生物组分析显示,S. mutans在脏活跃个体中更为普遍和丰富,支持其在牙中的作用.

科学领域:

微生物学微生物学
牙科研究牙科研究
口腔健康口腔健康

背景情况:

由于依赖单个物种识别,Streptococcus mutans作为牙损伤的主要原因的作用一直在争论中.
之前的研究往往忽视了全面的口腔微生物组合,限制了对*S. mutans*病因学意义的理解.

研究的目的:

系统地审查和评估虫活跃 (CA) 与无虫 (CF) 个体中的*S. mutans*的流行率和丰度.
分析调查口腔微生物组的临床研究,专注于*S. mutans*检测以及更广泛的微生物社区.

主要方法:

在PubMed,Cochrane和Embase数据库中进行了系统的文献搜索,截至2023年5月22日.
包括的研究分析了*S. mutans*和CA和CF个体的口腔微生物社区,使用基于DNA的方法.
关于患病率和相对丰度的数据被提取并使用随机效应模型元分析进行分析.

主要成果:

在19项符合条件的研究中,16项报告说,与CF相比,CA受试者中的*S.mutans*患病率更高.
报告相对丰度的所有11项研究都显示了CA个体中*S. mutans*的较高水平,从0.001%到5%不等.
微生物组数据分析没有确定其他细菌属或物种与空持续相关.

结论:

这种基于微生物组的证据强烈地将*S. mutans*的流行和丰富与脏病的经验联系在一起.
这些发现支持承认"S. mutans"在口腔生态系统中的空性作用.
需要进一步的研究,以充分阐明S. mutans在牙损伤发展中的具体机制和功能.

关键词:

16s 核糖体RNA 是一种牙斑块是指牙上的斑块.高通量核酸测序的测序我们的微生物群.实时的聚合酶连锁反应.这是唾液,唾液.

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