肝细胞癌的全身治疗,从早期到晚期:日本的观点
Masafumi Ikeda1, Chigusa Morizane2, Makoto Ueno3
1Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
Japanese journal of clinical oncology
|February 3, 2025
概括
系统疗法现在是治疗肝细胞癌 (HCC) 的主要重点,从向药物演变为免疫疗法. 对HCC的治疗选择需要仔细考虑疗效,副作用和肝功能.
科学领域:
- 肝胆道医学 肝胆道医学
- 医学瘤学 医学瘤学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 系统治疗越来越多地成为肝细胞癌 (HCC) 治疗的核心.
- 治疗模式正在从分子向治疗转向免疫治疗方案.
研究的目的:
- 审查目前HCC系统疗法的现状.
- 突出免疫疗法和组合治疗方法的演变.
- 强调基于疾病阶段,疗效和患者因素的个性化治疗选择的重要性.
主要方法:
- 审查目前的全身性药物和HCC的组合疗法.
- 分析不同疾病阶段 (早期,中期,晚期) 的治疗策略.
- 考虑治疗选择标准,包括疗效,不良事件和肝脏储备.
主要成果:
- 当免疫疗法不适用或失败时,使用分子向疗法 (例如索拉芬尼布,伦瓦提尼布).
- 免疫疗法组合 (例如,阿特佐利祖马布/贝瓦西祖马布,杜尔瓦卢马布/特梅利卢马布) 是一个重大进展.
- 系统疗法现在适用于HCC的所有阶段,通常与局部治疗相结合.
结论:
- 系统疗法是新型HCC治疗开发的主要重点.
- 个性化选择全身疗法,考虑到肝脏储备,至关重要.
- 针对所有HCC阶段,正在积极探索涉及全身和局部疗法的组合策略.
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