在积极监测前列腺癌的男性中进行丸激素替代疗法
James Applewhite1, Jacob McCarter1, Gal Saffati2
1Baylor College of Medicine, Houston, TX 77030, United States.
The journal of sexual medicine
|February 3, 2025
概括
在前列腺癌 (PCa) 积极监测的男性中,替代疗法 (TRT) 并没有显著改变PSA水平. 研究结果表明,与AS一般人群相比,疾病进展率相当.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 从历史上看,替代疗法 (TRT) 在积极监测 (AS) 的前列腺癌 (PCa) 的男性中是禁忌的.
- 新兴研究表明潜在的范式转变,挑战了TRT在这个患者群体中之前的禁忌.
研究的目的:
- 为了评估TRT对前列腺特异性抗原 (PSA) 水平的影响,在接受PCa的AS的低丸激素男性中.
- 评估TRT对该队列前列腺活检进展的影响.
主要方法:
- 对那些在AS上患有PCa的男性进行了回顾性分析,他们开始了TRT.
- 在TRT启动前和后记录PSA和水平.
- 通过使用统计方法,分析了活检数据,以确定疾病的进展.
主要成果:
- 包括43名男性;在TRT后,丸激素水平显著增加 (P<0.01).
- 没有观察到平均PSA水平的统计学上显著变化 (P = 0.87).
- 在15名接受监测活检的患者中,80%的患者在平均44.3个月内没有进展;20%的患者在平均79.5个月后获得格里森评分7的进展. 没有发生转移性疾病.
结论:
- 在男性中,TRT并没有导致PSA水平的显著变化,男性在PCa的AS上丸激素较低.
- 现有的活检数据表明没有增加PCa进展或疾病恶化.
- 研究结果表明,与AS一般人群相比,疾病进展率相似.
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