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相关实验视频

Updated: May 29, 2025

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

解码良性前列腺增生症:来自多流体代谢分析的见解

Xiaoyu Xu^1,2, Haisong Tan¹, Wei Zhang^1,3

¹Department of Urology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.

|February 3, 2025

概括

准确诊断良性前列腺增生症 (BPH) 是至关重要的. 这项研究使用MALDI MS确定了新的尿液和血清代谢模式和生物标志物,改善了早期BPH检测和个性化治疗策略.

关键词:

良性前列腺增生症良性前列腺增生症生物标志物生物标志物这是分类分类的分类.下泌尿道的症状症状代谢过程中的patten.

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相关实验视频

Last Updated: May 29, 2025

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

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Published on: November 26, 2015

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

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Published on: April 22, 2022

科学领域:

生物化学生物化学
医学诊断医学诊断医学诊断
分析化学分析化学

背景情况:

随着人口老龄化,良性前列腺增生症 (BPH) 的发病率不断上升,需要改进诊断方法.
目前的BPH诊断面临挑战,因为缺乏特定的生物标志物来区分它与其他导致下尿路症状 (LUTS) 的其他原因.

研究的目的:

开发和验证一个代谢检测平台,用于识别用于早期和准确的BPH诊断的新生物标志物.
用尿液和血清代谢模式将BPH与其他LUTS和健康个体区分开来.

主要方法:

使用纳米粒子辅助矩阵辅助激光脱/电离质谱 (MALDI MS) 代谢平台进行尿液和血清分析.
采用两步查方法:自动识别尿道代谢模式 (UMPs) 来区分健康与LUTS群体,其次是血清代谢模式 (SMPs) 来识别LUTS队列中的BPH.
确定了八种对BPH敏感的代谢标志物.

主要成果:

马尔迪MS平台展示了快速分析,最小的样本消耗和高可重复性.
在使用SMPs的LUTS队列中准确识别BPH病例的AUC达到0.830.
确定了八个BPH敏感的代谢标志物,在各年龄组均分布.

结论:

这种代谢学方法为早期诊断BPH提供了宝贵的见解.
鉴定的生物标志物和代谢模式可以增强临床实践和个性化BPH治疗策略.
这项研究有助于改善受BPH影响的老年人群的患者护理.