关节超运动和焦虑之间的神经过程:杏仁体和岛屿皮层的关键作用
Christina N Kampoureli1,2, Charlotte L Rae2, Cassandra Gould Van Praag3
1Department of Clinical Neuroscience, Brighton & Sussex Medical School, Falmer, UK.
The British journal of psychiatry : the journal of mental science
|February 3, 2025
概括
焦虑与由于大脑反应发生变化而导致关节过度运动有关. 神经成像揭示了威胁和身体状态处理中心的差异,这表明焦虑症超移动个体的新治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 增加的焦虑症状在具有关节多动性的个体中很普遍.
- 连接组织的变异可能会影响整感体表征,影响情绪处理.
- 了解神经支对于解决这个人群中的焦虑至关重要.
研究的目的:
- 通过功能神经成像来研究焦虑和超移动性的神经相关性.
- 为了探索大脑对情绪刺激的反应如何在焦虑和非焦虑的个体之间有和没有超移动性之间有所不同.
主要方法:
- 功能磁共振神经成像 (fMRI) 用于评估大脑活动.
- 参与者包括那些患有泛性焦虑障碍 (GAD) 和一个非焦虑的比较组.
- 评估了关节松,并使用布莱顿标准将参与者分类为超移动性谱系障碍 (HSD).
主要成果:
- 患有HSD的个体在观看情感面孔时表现出前额,中线和身区域的神经反应性降低.
- 在HSD和GAD患者中,HSD和焦虑之间的相互作用显示了左桃体和中部胰岛的强化反应.
- 杏仁体前功能连接在HSD的参与者中更强.
结论:
- 超移动个体对焦虑的倾向源于威胁处理 (杏仁体) 和身体状态表示神经中心 (岛屿,头顶) 之间的相互作用.
- 针对杏仁体反应性和感知精度的干预措施可能有利于有症状的超移动个体.
- 这项研究突出了连接组织,神经功能和焦虑之间的复杂相互作用.
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