基于瓜诺辛的双重功能水凝:在辐射诱导的口腔粘膜炎中提供高效的保护
Zihan Ding1, Xiaopei Hu1, Wenhui Liang1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management & Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China. zhaohangahy@scu.edu.cn.
Journal of materials chemistry. B
|February 3, 2025
概括
一种新的瓜诺辛聚乙醇 (G-PVA) 水凝有效地预防辐射诱导的口腔粘膜炎 (RIOM). 这种创新材料保护口腔组织免受辐射损伤,为接受放射治疗的癌症患者提供了一个有前途的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 放射治疗瘤学 放射治疗瘤学
- 药物输送系统 药物输送系统
背景情况:
- 辐射诱导的口腔粘膜炎 (RIOM) 是放射治疗的削弱性副作用.
- 目前对RIOM的治疗方法有限,需要新的治疗策略.
研究的目的:
- 开发和评估一种用于预防RIOM的新型瓜诺辛聚乙醇 (G-PVA) 超分子凝.
- 评估G-PVA水凝对辐射诱导的口腔组织损伤的保护作用.
主要方法:
- 为了制造G-PVA水凝,采用了一合成方法.
- 描述了水凝的特性,包括附着性和生物相容性.
- 评估了细胞对氧化应激和DNA损伤的保护 (γ-H2AX焦点).
- 在体内研究评估了水凝在减少RIOM严重性的有效性.
主要成果:
- 该G-PVA水凝表现出优异的湿粘度 (74.16 kPa),生物相容性和形状适应性.
- 水凝显著降低了氧化应激,并保护细胞免受辐射诱导的DNA损伤,减少了γ-H2AX焦点.
- 在体内,与对照组相比,G-PVA水凝将RIOM的相对部区域减少了52.23%.
结论:
- 开发的G-PVA超分子水凝在减轻氧化应激和防止直接辐射损伤方面表现出双重功能.
- 这种水凝显示出作为预防辐射诱导口腔粘膜炎的临床策略的巨大潜力.
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