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脂肪性肝病:导航病理特征,诊断挑战和新兴见解

Jingjing Jiao¹, Xuchen Zhang

¹Department of Pathology, Yale University School of Medicine, New Haven, CT.

Advances in anatomic pathology

|February 3, 2025

概括

脂肪性肝病 (SLD) 现在是一个广泛的类别,有五种亚型. 本综述涵盖了组织学评估,共同特征以及用于诊断SLD及其MASLD等亚型的数字病理学的进展.

科学领域:

肝病理学和病理学

背景情况:

脂肪性肝病 (Steatotic liver disease,简称SLD) 是指由脂肪积累为特征的肝脏疾病的总称.
它现在包括五个不同的子类别:与代谢功能障碍相关的脂肪性肝病 (MASLD),代谢和与酒精有关的/相关的肝病 (MetALD),与酒精有关的/相关的肝病 (ALD),具有特定病因的SLD和密码性SLD.

研究的目的:

审查性肝病 (SLD) 组织学评估的基础和最近的进展.
讨论共同的病理特征,病因之间的诊断区别,以及SLD的评分系统.
探索数字病理学在SLD评估中的作用.

主要方法:

关于SLD组织学的基础和最近研究的文献综述.
在SLD子类别中分析病理特征和诊断标准.
检查当前和新兴的数字病理学技术.

主要成果:

SLD的分类已经发展到包括MASLD,MetALD,ALD和其他特定病因.
组织学评估需要识别共同特征和病因学特定的区别.
数字病理学为标准化和准确的SLD评估提供了新的途径.

结论:

准确的组织学评估对于分类和管理各种形式的SLD至关重要.
通过数字病理学的帮助,标准化的评分和分级系统对于一致的SLD诊断至关重要.
了解SLD亚型的细微差别,包括MASLD,是有效的患者护理的关键.

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