囊淋巴瘤和相关实体的诊断和分类
Camille Laurent1, James R Cook2
1Department of Pathology, Toulouse University Hospital Center, Cancer Institute University of Toulouse-Oncopole, INSERM, France.
Advances in anatomic pathology
|February 3, 2025
概括
毛囊性淋巴瘤 (FL) 是一种B细胞瘤,通常与BCL2基因有关. 本综述涵盖了传统的FL及其变体,强调了诊断特征和分子研究.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 毛囊性淋巴瘤 (FL) 是一种成熟的B细胞瘤.
- 常规FL的特征是t(14;18) IGH::BCL2转位,导致BCL2过度表达.
- 早期的病变,如 in situ 毛囊瘤 (ISFN) 和十二指甲类型FL (DTFL) 是已知的变体.
研究的目的:
- 审查传统FL的关键病理和诊断特征.
- 总结FL的其他形式,包括BCL2重组负面病例.
- 强调分子研究在诊断FL及其变体中的作用.
主要方法:
- 关于卵泡淋巴瘤分类和诊断的文献综述.
- 对传统FL及其变体的病理和诊断标准的分析.
- 在FL工作中使用的分子技术的讨论.
主要成果:
- FL是一组异质的B细胞新生体.
- BCL2重排负的FL占10-15%的病例,包括不同的实体.
- 2022年国际共识分类将替代FL形式与传统FL区分开来.
结论:
- 精确诊断FL需要了解常规和替代形式.
- 分子研究对于区分FL亚型越来越重要.
- 区分FL变异对于适当的患者管理和治疗至关重要.
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