在患有直肠神经内分泌瘤的患者中,肠道微生物群的特性和功能
Yue Gao1, Hongxia Zheng1, Mujie Ye1
1Department of Geriatric Gastroenterology, Neuroendocrine Tumor Center, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China.
Journal of Cancer
|February 3, 2025
概括
肠道微生物群在直肠神经内分泌瘤 (rNETs) 中不同,与转移相关的特定细菌,如大肠杆菌和Alistipes. 某些微生物显示出作为rNET预测的生物标志物的潜力.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在癌症中的作用已经确立,但其在直肠神经内分泌瘤 (rNETs) 中的具体参与尚未得到充分理解.
- 了解这些微生物转变对于诊断和潜在治疗rNETs至关重要.
研究的目的:
- 研究患有rNETs的患者的肠道微生物群组成和功能.
- 识别微生物生物标志物,用于预测rNET存在和转移.
主要方法:
- 从健康对照组 (19) 和rNET患者 (21) 的便样本使用元基因组高通量测序进行了分析.
- 采用随机森林模型来确定rNET和转移性rNET (rNETs-M) 的预测性微生物生物标志物.
主要成果:
- rNET患者的肠道微生物多样性低于对照组;rNETs-M患者的肠道微生物多样性高于非转移性rNETs (rNETs-nM).
- 在rNET和rNETs-M组中分别观察到高水平的潜在病原体,如大肠杆菌,西格拉菌和阿里斯蒂普菌.
- 拉克诺斯皮拉 (Lachnospira pectinoschiza),帕拉苏特雷拉 (Parasutterella muris),索达利菲勒斯 (Sodaliphilus pleomorphus) 和梅西洛巴克特里亚 (Methylobacterium iners) 被确定为用于rNET预测的重要生物标志物.
结论:
- 在rNET患者中,肠道微生物群的组成发生了显著的变化,并且在转移性和非转移性疾病之间存在差异.
- 特定的微生物物种具有作为直肠神经内分泌瘤及其转移状态的诊断生物标志物的潜力.
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