用局部塔克罗利斯治疗的结膜淋巴细胞增生症:两例病例报告
Angeline C Rivkin1,2, Ashlie A Bernhisel2
1University of Illinois at Chicago College of Medicine, 1853 W Polk St, Chicago, IL, USA, 60612.
American journal of ophthalmology case reports
|February 3, 2025
概括
局部塔克罗利斯为结膜淋巴细胞增生提供了一种潜在的类固醇节约选择. 这种免疫调节药物在两名患者中显示了中度到完全的病变和症状改善.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 结膜性淋巴状增生症表现为刺激和结膜注射.
- 局部皮质类固醇是第一线药物,但具有眼内压力尖峰和白内障等风险.
- 类固醇节约剂被认为是长期管理.
研究的目的:
- 讨论局部塔克罗利斯对结膜淋巴状增生症的潜在益处.
- 在这种情况下,评估tacrolimus作为一种类固醇节约剂.
主要方法:
- 两个结膜性淋巴细胞增生病例在下中用局部0.03%的塔克罗利斯治疗.
- 对患者进行临床和症状改善的监测.
主要成果:
- 两位患者对最初的类固醇治疗都有积极反应,但由于眼内压力升高,需要使用类固醇节约的选择.
- 局部塔克罗利斯导致结膜病变的中度到完全消失.
- 在这两位患者中都观察到症状改善.
结论:
- 局部塔克罗利斯是一种潜在的类固醇节约治疗结膜淋巴细胞增生症.
- 这代表了新的,非标签使用tacrolimus对于这个特定的眼睛条件.
- 需要进一步的研究来证实有效性和安全性.
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