神经性厌食症的过度控制:在工作记忆任务中增加了前额活动和杏仁体连接,其中包括食物分心器
Sophie Pauligk1, Maria Seidel1, Franziska Ritschel1
1Division of Psychological and Social Medicine and Developmental Neuroscience, Translational Developmental Neuroscience Section, Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
International journal of clinical and health psychology : IJCHP
|February 3, 2025
概括
患有神经性厌食症 (AN) 的人表现出过度的自上而下的控制,由背侧前额叶皮质 (dlPFC) 中大脑活动的增加表明. 这种过度控制,即使在不相关的食物线索中也被观察到,表明AN的潜在神经基质.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 神经性厌食症 (AN) 与过度的自我控制或"过度控制"有关.
- 以前的研究表明,在AN中,前脑活动增加,特别是在明确的食物刺激下.
- 目前尚不清楚,当食物线索与任务无关时,这些变化是否会持续下去.
研究的目的:
- 为了研究与无关食物刺激的任务期间与AN的个体的神经活动和连接.
- 为了检查背侧前额皮质 (dlPFC) 和杏仁体在AN上下控制中的作用.
- 为了确定AN中的大脑变化是否依赖于刺激.
主要方法:
- 功能性磁共振成像 (fMRI) 用于32名急性疾病妇女和32名健康对照.
- 参与者完成了一项工作记忆2-back任务,使用高热量食物图像作为分心.
- 分析的重点是dlPFC和杏仁体活动和连接性.
主要成果:
- 在任务执行方面没有观察到任何显著的群体差异.
- 与对照组相比,患有AN的个体表现出较高的左 dlPFC 活性,无论刺激类型如何.
- AN参与者表现出左 dlPFC 和双边杏仁体之间的负连接性增加.
结论:
- 增加的dlPFC激活和改变的dlPFC-杏仁体连接性表明,在AN中存在过度的上下控制.
- 这些神经模式可能代表过度控制的基质,独立于外部刺激.
- 这种过度控制机制可能是AN的潜在治疗目标.
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