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普兰托西亚尼丁囊通过调节MAPK信号来重塑ROS微环境,以加速糖尿病伤口愈合

Shaoyin Wei^1,2,3, Dong Yang², Zeyu Shou⁴

¹School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, China.

Materials today. Bio

|February 3, 2025

概括

这项研究开发了proanthocyanidin (PC) 囊,以提高生物可用性,促进糖尿病伤口愈合. 囊有效地清除自由基,调节炎症路径,加速糖尿病小鼠的恢复.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
药理学药理学是指药理学的学科.

背景情况:

缺陷的糖尿病伤口愈合是一个重要的临床问题.
糖尿病伤口中的高血糖会增加活性氧物种 (ROS),激活MAPK通路,导致炎症和细胞损伤.
多在伤口愈合方面表现有前途,但其生物可用性较差.

研究的目的:

开发一种方法来制备具有增强生物可用性的普罗安托西亚尼丁 (PC) 囊.
调查PC囊在加快糖尿病伤口愈合方面的疗效.
探索PC囊对MAPK路径和伤口微环境的作用的潜在机制.

主要方法:

开发PC囊使用结和疏水性相互作用.
给患有伤口的糖尿病小鼠服用单剂量PC囊.
评估了伤口愈合的进展,炎症媒介水平,细胞亡和MAPK通路激活 (p38 MAPK).

主要成果:

PC囊表现出持续的自由基清除和持续的 proanthocyanidin 释放,显著改善生物可用性.
一次剂量的PC囊在糖尿病小鼠中加速了伤口愈合.
治疗调节了p38 MAPK信号级联,减少了炎症媒介,抑制了亡,并重塑了伤口微环境.

结论:

PC囊提供了一种有前途的策略,用于增强多生物可用性,用于治疗糖尿病伤口愈合.
通过PC囊调节MAPK通路为炎症和与氧化压力相关的疾病提供了潜在的治疗方法.
这项研究有助于开发针对复杂的伤口愈合挑战的新型治疗方法.

关键词:

囊囊囊囊囊糖尿病的伤口炎症炎症是一种炎症.氨基氨基氨基酸是什么?p38 MAPK路径的使用

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MAPK Signaling Cascades

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...